This information does not contain all possible interactions or adverse effects. Visit the RxList Drug Interaction Checker for any drug interactions. Therefore, before using this product, tell your doctor or pharmacist about all your products.

Opioid-Induced Hyperalgesia And Allodynia

If a decision is made to treat serious respiratory depression in the physically dependent patient, administration of the antagonist should be initiated with care and by titration with smaller than usual doses of the antagonist. All patients treated with opioids require careful and frequent reevaluation for signs of misuse, abuse, and addiction, because use of opioid analgesic products carries the risk of addiction even under appropriate medical use. Patients at high risk of ROXICODONE abuse include those with a history of prolonged use of any opioid, including products containing oxycodone, those with a history of drug or alcohol abuse, or those who use ROXICODONE in combination with other abused drugs. Inform patients that opioids could cause a rare but potentially life-threatening condition resulting from concomitant administration of serotonergic drugs. Warn patients of the symptoms of serotonin syndrome percocet: uses, dosage, side effects warnings and to seek medical attention right away if symptoms develop.

Drug/Laboratory Test Interactions

Initiate therapy with a lower than usual dosage of ROXICODONE and titrate carefully. Monitor infants exposed to ROXICODONE through breast milk for excess sedation and respiratory depression. Withdrawal symptoms can occur in breastfed infants when maternal administration of an opioid analgesic is stopped or when breastfeeding is stopped. Patients should be advised not to adjust the dose of ROXICODONE without consulting the prescribing healthcare provider see DOSAGE AND ADMINISTRATION.

Common side effects of oxycodone

• ROXICODONE may impair the mental or physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery.
• Oxycodone-Naloxone is a prescription medication used to relieve chronic pain.
• Some side effects of oxycodone may occur that usually do not need medical attention.
• These estimates based on maternal breastmilk concentrations were corroborated by the observed infant concentrations, of which over 75% (19/25) were below the limit of quantification.
• Inform patients that accidental ingestion, especially by children, may result in respiratory depression or death see WARNINGS.

Ask your healthcare professional how you should dispose of any medicine you do not use. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases.

This may help prevent worsening of your condition and reduce the possibility of withdrawal symptoms, including stomach cramps, anxiety, fever, irritability, nausea, restlessness, runny nose, sweating, tremors, or trouble with sleeping. Follow patients for signs and symptoms of respiratory depression and sedation. Opioid antagonists, such as naloxone, are specific antidotes to respiratory depression resulting from opioid overdose.

Medical Uses

Advise breastfeeding women using PERCOCET to carefully observe infants for increased sleepiness (more than usual), breathing difficulties, or limpness. Instruct breastfeeding women to seek immediate medical care if they notice these signs see PRECAUTIONS; Nursing Mothers. Inform patients that accidental ingestion, especially by children, may result in respiratory depression or death see WARNINGS. PERCOCET may impair the mental or physical abilities needed to perform potentially hazardous activities such as driving a car or operating machinery. Warn patients not to drive or operate dangerous machinery unless they are tolerant to the effects of PERCOCET and know how they will react to the medication see PRECAUTIONS; Information for Patients/Caregivers. The administration of PERCOCET, or other opioids may obscure the diagnosis or clinical course in patients with acute abdominal conditions.

The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for PERCOCET and any potential adverse effects on the breastfed infant from PERCOCET or from the underlying maternal condition. The concomitant use of anticholinergic drugs may increase risk of urinary retention and/or severe constipation, which may lead to paralytic ileus. Urine testing for opiates may be performed to determine illicit drug use and for medical reasons such as evaluation of patients with altered states of consciousness or monitoring efficacy of drug rehabilitation efforts.

Wisconsin Drug and Alcohol Statistics

There is inter-patient variability in the potency of opioid drugs and opioid formulations. Therefore, a conservative approach is advised when determining the total daily dosage of ROXICODONE. It is safer to underestimate a patient’s 24-hour ROXICODONE dosage than to overestimate the 24-hour ROXICODONE dosage and manage an adverse reaction due to overdose. If a patient has been receiving opioid-containing medications prior to taking ROXICODONE, the potency of the prior opioid relative to oxycodone should be factored into the selection of the total daily dose (TDD) of oxycodone.

• Manifestations of histamine release and/or peripheral vasodilatation may include pruritus, flushing, red eyes, sweating, and/or orthostatic hypotension.
• Initiate the dosing regimen for each patient individually, taking into account the patient’s underlying cause and severity of pain, prior analgesic treatment and response, and risk factors for addiction, abuse, and misuse see WARNINGS.
• Educate patients and caregivers on how to recognize respiratory depression and emphasize the importance of calling 911 or getting emergency medical help right away in the event of a known or suspected overdose see WARNINGS; Life-Threatening Respiratory Depression.
• There is a relationship between increasing oxycodone plasma concentration and increasing frequency of dose-related opioid adverse reactions such as nausea, vomiting, CNS effects, and respiratory depression.
• Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals.

Reserve concomitant prescribing of these drugs for use in patients for whom alternative treatment options are inadequate. Inform patients and caregivers of this potential interaction, educate them on the signs and symptoms of respiratory depression (including sedation). If concomitant use is warranted, consider prescribing naloxone for the emergency treatment of opioid overdose see WARNINGS.

This is understandable as both are opioid pain medications, and both have been in the news a lot due to the opioid epidemic. Accidental ingestion can result in a fatal overdose, especially in children. Our website provides access to information and support for people seeking help. We are not a medical center or doctors and cannot prescribe treatment. Our free phone numbers and chats allow you to connect with various institutions where you can receive professional help.

These may be symptoms of opioid-induced hyperalgesia and allodynia. To prevent this, your doctor may direct you to take laxatives, drink a lot of fluids, or increase the amount of fiber in your diet. Be sure to follow the directions carefully, because continuing constipation can lead to more serious problems. The dose of this medicine will be different for different patients.